ParkinsonCanadaV1, Main, Exploration, bibRecord, 001686

Diffusion tensor imaging and olfactory identification testing in early-stage Parkinson's disease.

Identifieur interne : 001686 ( Main/Exploration ); précédent : 001685; suivant : 001687

Diffusion tensor imaging and olfactory identification testing in early-stage Parkinson's disease.

Auteurs : Tyler M. Rolheiser [Canada] ; Heather G. Fulton ; Kimberley P. Good ; John D. Fisk ; J Roger Mckelvey ; Christophe Scherfler ; Naeem M. Khan ; Ronald A. Leslie ; Harold A. Robertson

Source :

Journal of neurology [ 1432-1459 ] ; 2011.

RBID : pubmed:21287185

English descriptors

KwdEn :
- Brain (pathology), Brain Mapping, Diffusion Magnetic Resonance Imaging (methods), Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Olfaction Disorders (diagnosis), Olfaction Disorders (etiology), Parkinson Disease (complications), Parkinson Disease (diagnosis).
MESH :
- complications : Parkinson Disease.
- diagnosis : Olfaction Disorders, Parkinson Disease.
- etiology : Olfaction Disorders.
- methods : Diffusion Magnetic Resonance Imaging.
- pathology : Brain.
- Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged.

Abstract

Evidence from imaging, clinical studies, and pathology suggests that Parkinson's disease is preceded by a prodromal stage that predates clinical diagnosis by several years but there is no established method for detecting this stage. Olfactory impairment, which is common in Parkinson's disease and often predates clinical diagnosis, may be a useful biomarker for early Parkinson's. Evidence is emerging that diffusion imaging parameters might be altered in olfactory tract and substantia nigra in the early stages of clinical Parkinson's disease, possibly reflecting pathological changes. However, no study has examined olfaction and diffusion imaging in olfactory tract and substantia nigra in the same group of patients. The present study compared newly diagnosed Parkinson's disease patients with a matched control group using both olfactory testing and diffusion tensor imaging of the substantia nigra and anterior olfactory structures. Fourteen patients with stage 1-2 Hoehn & Yahr Parkinson's disease were matched to a control group by age and sex. All subjects then completed the University of Pennsylvania Smell Identification Test, as well as a series of MRI scans designed to examine diffusion characteristics of the olfactory tract and the substantia nigra. Olfactory testing revealed significant impairment in the patient group. Diffusion tensor imaging revealed significant group differences in both the substantia nigra and anterior olfactory region, with fractional anisotropy of the olfactory region clearly distinguishing the Parkinson's subjects from controls. This study suggests that there may be value in combining behavioral (olfaction) and MRI testing to identify early Parkinson's disease. Since loss of olfaction often precedes the motor symptoms in Parkinson's disease, the important question raised is "will the combination of olfactory testing and MRI (DTI) testing identify pre-motor Parkinson's disease?"

DOI: 10.1007/s00415-011-5915-2
PubMed: 21287185

Affiliations:

Canada

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Diffusion tensor imaging and olfactory identification testing in early-stage Parkinson's disease.</title>
<author><name sortKey="Rolheiser, Tyler M" sort="Rolheiser, Tyler M" uniqKey="Rolheiser T" first="Tyler M" last="Rolheiser">Tyler M. Rolheiser</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology, Dalhousie University, Halifax, NS, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Pharmacology, Dalhousie University, Halifax, NS</wicri:regionArea>
<wicri:noRegion>NS</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fulton, Heather G" sort="Fulton, Heather G" uniqKey="Fulton H" first="Heather G" last="Fulton">Heather G. Fulton</name>
</author>
<author><name sortKey="Good, Kimberley P" sort="Good, Kimberley P" uniqKey="Good K" first="Kimberley P" last="Good">Kimberley P. Good</name>
</author>
<author><name sortKey="Fisk, John D" sort="Fisk, John D" uniqKey="Fisk J" first="John D" last="Fisk">John D. Fisk</name>
</author>
<author><name sortKey="Mckelvey, J Roger" sort="Mckelvey, J Roger" uniqKey="Mckelvey J" first="J Roger" last="Mckelvey">J Roger Mckelvey</name>
</author>
<author><name sortKey="Scherfler, Christophe" sort="Scherfler, Christophe" uniqKey="Scherfler C" first="Christophe" last="Scherfler">Christophe Scherfler</name>
</author>
<author><name sortKey="Khan, Naeem M" sort="Khan, Naeem M" uniqKey="Khan N" first="Naeem M" last="Khan">Naeem M. Khan</name>
</author>
<author><name sortKey="Leslie, Ronald A" sort="Leslie, Ronald A" uniqKey="Leslie R" first="Ronald A" last="Leslie">Ronald A. Leslie</name>
</author>
<author><name sortKey="Robertson, Harold A" sort="Robertson, Harold A" uniqKey="Robertson H" first="Harold A" last="Robertson">Harold A. Robertson</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2011">2011</date>
<idno type="RBID">pubmed:21287185</idno>
<idno type="pmid">21287185</idno>
<idno type="doi">10.1007/s00415-011-5915-2</idno>
<idno type="wicri:Area/PubMed/Corpus">000C02</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000C02</idno>
<idno type="wicri:Area/PubMed/Curation">000C02</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000C02</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000C02</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000C02</idno>
<idno type="wicri:Area/Ncbi/Merge">000E19</idno>
<idno type="wicri:Area/Ncbi/Curation">000E19</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000E19</idno>
<idno type="wicri:Area/Main/Merge">001758</idno>
<idno type="wicri:Area/Main/Curation">001686</idno>
<idno type="wicri:Area/Main/Exploration">001686</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Diffusion tensor imaging and olfactory identification testing in early-stage Parkinson's disease.</title>
<author><name sortKey="Rolheiser, Tyler M" sort="Rolheiser, Tyler M" uniqKey="Rolheiser T" first="Tyler M" last="Rolheiser">Tyler M. Rolheiser</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology, Dalhousie University, Halifax, NS, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Pharmacology, Dalhousie University, Halifax, NS</wicri:regionArea>
<wicri:noRegion>NS</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fulton, Heather G" sort="Fulton, Heather G" uniqKey="Fulton H" first="Heather G" last="Fulton">Heather G. Fulton</name>
</author>
<author><name sortKey="Good, Kimberley P" sort="Good, Kimberley P" uniqKey="Good K" first="Kimberley P" last="Good">Kimberley P. Good</name>
</author>
<author><name sortKey="Fisk, John D" sort="Fisk, John D" uniqKey="Fisk J" first="John D" last="Fisk">John D. Fisk</name>
</author>
<author><name sortKey="Mckelvey, J Roger" sort="Mckelvey, J Roger" uniqKey="Mckelvey J" first="J Roger" last="Mckelvey">J Roger Mckelvey</name>
</author>
<author><name sortKey="Scherfler, Christophe" sort="Scherfler, Christophe" uniqKey="Scherfler C" first="Christophe" last="Scherfler">Christophe Scherfler</name>
</author>
<author><name sortKey="Khan, Naeem M" sort="Khan, Naeem M" uniqKey="Khan N" first="Naeem M" last="Khan">Naeem M. Khan</name>
</author>
<author><name sortKey="Leslie, Ronald A" sort="Leslie, Ronald A" uniqKey="Leslie R" first="Ronald A" last="Leslie">Ronald A. Leslie</name>
</author>
<author><name sortKey="Robertson, Harold A" sort="Robertson, Harold A" uniqKey="Robertson H" first="Harold A" last="Robertson">Harold A. Robertson</name>
</author>
</analytic>
<series><title level="j">Journal of neurology</title>
<idno type="eISSN">1432-1459</idno>
<imprint><date when="2011" type="published">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Brain (pathology)</term>
<term>Brain Mapping</term>
<term>Diffusion Magnetic Resonance Imaging (methods)</term>
<term>Female</term>
<term>Humans</term>
<term>Image Processing, Computer-Assisted</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Olfaction Disorders (diagnosis)</term>
<term>Olfaction Disorders (etiology)</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (diagnosis)</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Olfaction Disorders</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Olfaction Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Diffusion Magnetic Resonance Imaging</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Brain Mapping</term>
<term>Female</term>
<term>Humans</term>
<term>Image Processing, Computer-Assisted</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Evidence from imaging, clinical studies, and pathology suggests that Parkinson's disease is preceded by a prodromal stage that predates clinical diagnosis by several years but there is no established method for detecting this stage. Olfactory impairment, which is common in Parkinson's disease and often predates clinical diagnosis, may be a useful biomarker for early Parkinson's. Evidence is emerging that diffusion imaging parameters might be altered in olfactory tract and substantia nigra in the early stages of clinical Parkinson's disease, possibly reflecting pathological changes. However, no study has examined olfaction and diffusion imaging in olfactory tract and substantia nigra in the same group of patients. The present study compared newly diagnosed Parkinson's disease patients with a matched control group using both olfactory testing and diffusion tensor imaging of the substantia nigra and anterior olfactory structures. Fourteen patients with stage 1-2 Hoehn & Yahr Parkinson's disease were matched to a control group by age and sex. All subjects then completed the University of Pennsylvania Smell Identification Test, as well as a series of MRI scans designed to examine diffusion characteristics of the olfactory tract and the substantia nigra. Olfactory testing revealed significant impairment in the patient group. Diffusion tensor imaging revealed significant group differences in both the substantia nigra and anterior olfactory region, with fractional anisotropy of the olfactory region clearly distinguishing the Parkinson's subjects from controls. This study suggests that there may be value in combining behavioral (olfaction) and MRI testing to identify early Parkinson's disease. Since loss of olfaction often precedes the motor symptoms in Parkinson's disease, the important question raised is "will the combination of olfactory testing and MRI (DTI) testing identify pre-motor Parkinson's disease?"</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
</country>
</list>
<tree><noCountry><name sortKey="Fisk, John D" sort="Fisk, John D" uniqKey="Fisk J" first="John D" last="Fisk">John D. Fisk</name>
<name sortKey="Fulton, Heather G" sort="Fulton, Heather G" uniqKey="Fulton H" first="Heather G" last="Fulton">Heather G. Fulton</name>
<name sortKey="Good, Kimberley P" sort="Good, Kimberley P" uniqKey="Good K" first="Kimberley P" last="Good">Kimberley P. Good</name>
<name sortKey="Khan, Naeem M" sort="Khan, Naeem M" uniqKey="Khan N" first="Naeem M" last="Khan">Naeem M. Khan</name>
<name sortKey="Leslie, Ronald A" sort="Leslie, Ronald A" uniqKey="Leslie R" first="Ronald A" last="Leslie">Ronald A. Leslie</name>
<name sortKey="Mckelvey, J Roger" sort="Mckelvey, J Roger" uniqKey="Mckelvey J" first="J Roger" last="Mckelvey">J Roger Mckelvey</name>
<name sortKey="Robertson, Harold A" sort="Robertson, Harold A" uniqKey="Robertson H" first="Harold A" last="Robertson">Harold A. Robertson</name>
<name sortKey="Scherfler, Christophe" sort="Scherfler, Christophe" uniqKey="Scherfler C" first="Christophe" last="Scherfler">Christophe Scherfler</name>
</noCountry>
<country name="Canada"><noRegion><name sortKey="Rolheiser, Tyler M" sort="Rolheiser, Tyler M" uniqKey="Rolheiser T" first="Tyler M" last="Rolheiser">Tyler M. Rolheiser</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001686 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001686 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Canada
   |area=    ParkinsonCanadaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:21287185
   |texte=   Diffusion tensor imaging and olfactory identification testing in early-stage Parkinson's disease.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:21287185" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a ParkinsonCanadaV1

This area was generated with Dilib version V0.6.29.
Data generation: Thu May 4 22:20:19 2017. Site generation: Fri Dec 23 23:17:26 2022

La maladie de Parkinson au Canada (serveur d'exploration)

Diffusion tensor imaging and olfactory identification testing in early-stage Parkinson's disease.

Diffusion tensor imaging and olfactory identification testing in early-stage Parkinson's disease.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.